Synthesis of Schiff’s Bases from 2-Amino-4H-1, 3-Oxazine / Thiazine and Substituted Aldehydes and their Transition Metal Complexes

Objective: Many methods can be found in literature for the synthesis a Oxazines and Thiazines. Few are reported one-pot multi component cyclo-condensation of an alkayane urea / Thiourea Aldehyde to 2- amino-4H-1, 3-Oxazines or Different catalysts like Trifluoro-acetic acid, glacial acetic acid under reflux condition Mandal Co-workers have utilized perchloric (HClO4) supported on silica gel as catalyst solvent free ytterbium trifluorate [Yb(OTF)3] plays role Lewis acid. It is also used several Diel’s-Alder cyclo-addition reactions. Inspired these observations, development simple effective synthetic strategy 2-amino-4H-1, 3-Oxazium & Thiazines was attempted. Material Methods: One pot multi-component Schiff’s base new ligand their complexes with Ni, Fe, Co Cu developed using 2-amino-4H-1,3 /Thiazines substituted Aldehydes, different synthesize 2-amino 4H-1,3 Oxazines. Its characterization confirmed by taking IR, NMR spectra. The act bidentate, when it treated metal 1:1 ratio (metal: ligand) formed. Result: By bioactive molecules 3 Oxazine Thiazines, Bases synthesized aldehydes. These has antitumor, antipyretic, anti-inflammatory property. And bases metals Co, Cu, Zn which enhances bio-activity. Conclusion: All Schiff’ having properties.